Teams

Neuroplasticity in Parkinson's disease
Neuroplasticity in Parkinson's disease

Véronique Sgambato (Principal Investigator,Tenured Researcher INSERM)
email: veronique.sgambato@inserm.fr
phone: (334) 37 91 12 49

Véronique Sgambato is a neurobiologist (Researcher ID: G-9062-2017; ORCID: 0000-0002-8792-8586). She obtained her PhD in Neuroscience in 1998 from the University Pierre et Marie Curie in Paris (Ph.D. director Prof. Jean-Michel Deniau; Laboratory of Neuroanatomy and Neurochemistry headed by Prof. Marie-Jo Besson). After two postdoctoral trainings in the USA in the laboratories of Prof. Steven E. Hyman (Molecular Plasticity Section, NINDS, NIH, Bethesda, MD) and of Prof. Paul Greengard (Nobel Prize in Medicine in 2000; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New-York City), she got an academic position in 2002 as a research scientist at INSERM, the French National Institute of Health and Medical Research. From 2003 to 2008, she worked in Grenoble (laboratories of Prof. Alim-Louis Benabid, INSERM U318 Preclinical Neuroscience and then of Dr. Marc Savasta, Grenoble Institute of Neuroscience) to investigate the impact of deep brain stimulation and levodopa treatment, the two major symptomatic treatments for Parkinson’s disease (PD), on the plasticity of basal ganglia neurons by combining behavioral, biochemical and immunohistochemical approaches on rodent models. In 2009, she moved to Lyon to join the Institute of cognitive Sciences Marc Jeannerod (Mixt Research Unit 5229 from the Scientific Research National Center (CNRS) and University of Lyon 1) and focused her research on the role of the serotonergic system in the pathophysiology of motor and non-motor symptoms in PD by combining behavioral, imaging and anatomical approaches on primates. Since January 1st, 2021, she leads a research team entitled “Neuroplasticity in Parkinson’s disease”. Dr Sgambato was President of the French basal ganglia club from june 2018 to january 2023. She is actually member of scientific committee of France Parkinson and associate editor for Nature Journal of Parkinson's disease. Dr Sgambato’s work is supported by the CNRS, Université de Lyon, Fondation de France, Fondation Neurodis, France Parkinson and Agence Nationale de la Recherche.

More
Chrystelle Castano (Neuropsychologist)
email: chrystelle.castano@club-internet.fr
phone: (334) 74 31 34 29

Chrystelle Castano-Francony is a neuropsychologist.

After three years studying Clinical and Psychopathological Psychology in the University of Lyon, she integrated a Neurosciences Cognitives Master and specialized herself through a DESS Neuropsychology of the University of Savoie (Chambery, 1996).

She has completed her cursus with an Emotional Freedom Techniques certificate (EFT France school) in 2010 and recently validates a BPC formation in 2021.

Since 1996, she works in the Neurological department of the Hospital of Vienne (Isere, France) and since 2012 joins the Rehabilitation département of the same structure.

Her fields of interest in Neuropsychology are executive functions, comportemental disorders and episodic memory, focus on adult patients with several brain injuries and neurological pathologies, like Parkinson’s disease.

More
Rossella Cirillo (Post-doctorant)
email: rossella.cirillo@gmail.com
phone: (334) 37 91 13 32

Rossella Cirillo started working in research laboratories in 2009 in the Laboratory of Developmental Psychobiology and Behavioral Genetics in Rome where she participated in a research project to study the genotype-dependent differences in coping strategies.

She then worked in the Laboratory of Medical Pharmacology at Sapienza University (Rome, Italy) to study the c-fos protein expression induced by cocaine and heroin-taking in rat striatal dopamine neurons.

Her PhD experience (2013-2017) took place at the Laboratory of Behavioral Neurophysiology at Sapienza University in Rome where she started to study the role of primate cortical neurons in social interaction, focusing on the brain areas normally involved in Autism Spectrum Disorder.

In 2017 she started to work at the Institut des Sciences Cognitives (ISC) as a Post Doc. The first project concerned the study of social brain’s structures in non-human primates.

Since January 2020 she works in the team of Véronique Sgambato to study behavioral disorders on non-human primates with Parkinson-induced symptoms and the brain structures involved in this neurodegenerative disease.

More
Sandra Duperrier (Engineer assistant CNRS)
email: sandra.duperrier@isc.cnrs.fr
phone: (334) 37 91 13 32

Sandra Duperrier is an assistant engineer.

She has knowledge in microbiology, molecular biology and histology. She worked at the Institut Pasteur in Paris on the development of a Listeria biodiversity chip and on improving the growth of Legionella. She joined the CNRS in 2006 as an engineer assistant, at the Institut de Biologie Physico-Chimique in Paris, and worked on the search for a sigma factor inhibitor of sporulation in Bacillus subtilis. 

In 2013, she moved to the Lyon region to join the Institut des Sciences Cognitives Marc Jeannerod. Since then, Sandra Duperrier actively participates in the study project on the role of serotonin in motor and non-motor symptoms in Parkinson's disease, under Dr V. Sgambato’s supervision.

More
Alexis Lepetit (Psychiatrist and Geriatrician)
email: alexis.lepetit@chu-lyon.fr
phone: (334) 72 43 23 26

Dr Alexis Lepetit is a psychiatrist and geriatrician.

Since the beginning of his psychiatric training, Dr Alexis Lepetit has been interested in Old Age Psychiatry (OAP). To improve his skills in this subspecialty, he decided to complete his training with a geriatric medical degree. 

Dr Lepetit’s current position enables him to develop research and teaching projects in both psychiatry and neurology. Dr Lepetit supervises medical residents for their theses. These theses are also published as research articles in peer-reviewed journals. 

Dr Alexis Lepetit has a keen interest in psychopharmacology that enabled him to participate as principal investigator or co-investigator in pharmaceutical trials.

On the other hand, he is a founding member of the French association of early-career psychiatrists (AJPJA, www.ajpja.fr). This associative commitment directly followed his 2 years as a board member of the French association of psychiatric trainees (AFFEP, www.affep.fr). During this mandate, the first taskforce on OAP has been created to make it an official psychiatric subspecialty in France with the full support of the French association of professors of psychiatry, the OAP section of the EPA, the European Association of Geriatric Psychiatry and the WPA. 

Dr Alexis Lepetit is also involved in the promotion of OAP in France, being deputy general secretary of the French Old Age Psychiatry Society (SF3PA).

More
Pathik Parekh (PhD student)
email: pparekh@isc.cnrs.fr

Pathik Parekh pursued his master’s degree from the National Institute of Pharmaceutical Education and Research (NIPER) in India in 2017. Where he studied the role of autophagy in the neurotoxin-based animal model of Parkinson’s disease (PD). 

He is pursuing his Ph.D. from the University of Cagliari, Italy where his main goal is to investigate the neuroprotective and anti-inflammatory potential of natural products in the preclinical model of PD. 

As a part of his Ph.D. program, recently he joined the team of Prof. Véronique Sgambato at the Institute of Cognitive Sciences, Lyon to study behavioral disorders in the non-human primates which recapitulate symptoms of PD and to understand the brain structures involved behind the observed neurodegeneration in PD.

More
Alix Saude (Masters student)
email: alix.saude@univ-lyon2.fr

Alix Saude is pursuing his master’s degree of cognitive sciences, neuropsychology and clinical neurosciences at the Lyon 2 University, France.

As a part of his master’s program, he recently joined the Neuroplasticity in Parkinson’s disease’s team under the supervision of V. Sgambato, to study behavioral disorders in the Parkinson’s disease and learn more about the research field.

More
Anne-Evelyne Vallet (Neurologist)
email: ae.vallet@ch-vienne.fr
phone: (334) 74 31 34 29

Dr Anne-Evelyne Vallet is a neurologist.

Dr Vallet has a training both in neuroscience with the Ecole Normale Superieure (Lyon) and in medicine.

Dr Vallet completed her training in 2007, and then worked for 3 years with Prof Broussolle in his team in the department of movement disorders in the Neurological hospital of Lyon, France.

Since 2011, Dr Vallet been working in the neurological department of the general hospital of Vienne (Isere, France) . Her fields of interest in neurology include movement disorders, neuromuscular disorders and stroke.

More
Jing Xie (Neurologist)
email: jing.xie@chu-lyon.fr
phone: (334) 72 43 20 44

Jing XIE is a neurologist (RPPS: 10005166839). 

She obtained her medical degree in 1987 from the Shanghai Jian Tong medical university, China. She works in France as a neurologist since 1995 and obtained her PhD in Neurosciences in 2001 from the Joseph-Fourier University in Grenoble. She got the equivalence doctor in medicine in France in 2008. 

From 1995 to 2000, she worked in the neurological service of Prof Pollak, CHU de Grenoble. From 2002 to 2009, she worked in the neurological service of Prof Broussolle, Hôpital Neurologique, Lyon. During these years, she primarily treated Parkinsonian patients and patients with movement disorders. She has been involved in numerous clinical researches on Parkinson’s disease. Since 2012, she works as co-head in the clinical and research memory center of Lyon. She works on neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. She participates in clinical research and teaching.

More

Institut des Sciences Cognitives "Marc Jeannerod" | Copyright © 2019-2021