Physiopathologie des ganglions de la base
Léon Tremblay (Principal Investigator)

Phone: +33 (0)4 37 91 12 24

  • Guillaume Becker, Justine Debatisse, Margaux Riviére, Claire Crola Da Silva, Maude Beaudoin-Gobert, Omer Eker, Ocèane Wateau, Tae Hee Cho, Marléne Wiart, Lèon Tremblay, Nicolas Costes, Inés Mèrida, Jèrôme Redoutè, Christelle Lèon, Jean-Baptiste Langlois, Didier Le Bars, Sophie Lancelot, Norbert Nighoghossian, Laura Mechtouff, Emmanuelle Canet-Soulas
    Spatio-Temporal Characterization of Brain Inflammation in a Non-human Primate Stroke Model Mimicking Endovascular Thrombectomy
    Neurotherapeutics, (2023), doi: 10.1007/s13311-023-01368-2
  • Stèphane Prange, Elise Metereau, Audrey Maillet, Hèléne Klinger, Emmanuelle Schmitt, Eugènie Lhommèe, Amèlie Bichon, Sophie Lancelot, Sara Meoni, Emmanuel Broussolle, Anna Castrioto, Lèon Tremblay, Paul Krack, Stèphane Thobois
    Limbic Serotonergic Plasticity Contributes to the Compensation of Apathy in Early Parkinson's Disease
    Movement Disorders, 1211--1221, Vol: 37, (2022), doi: 10.1002/mds.28971
  • Yosuke Saga, Laurent Galineau, Lèon Tremblay
    Impulsive and compulsive behaviors can be induced by opposite GABAergic dysfunctions inside the primate ventral pallidum
    Frontiers in Systems Neuroscience, Vol: 16, (2022), doi: 10.3389/fnsys.2022.1009626
  • Audrey Maillet, Elise Mètèreau, Lèon Tremblay, Emilie Favre, Hèléne Klinger, Eugènie Lhommèe, Didier Le Bars, Anna Castrioto, Stèphane Prange, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
    Serotonergic and Dopaminergic Lesions Underlying Parkinsonian Neuropsychiatric Signs
    Movement Disorders, 2888--2900, Vol: 36, (2021), doi: 10.1002/mds.28722
  • Eva Martinez, Benjamin Pasquereau, Guillaume Drui, Yosuke Saga, Èlise Mètèreau, Lèon Tremblay
    Ventral striatum supports Methylphenidate therapeutic effects on impulsive choices expressed in temporal discounting task
    Scientific Reports, Vol: 10, (2020), doi: 10.1038/s41598-020-57595-6
  • Stèphane Prange, Elise Metereau, Audrey Maillet, Eugènie Lhommèe, Hèléne Klinger, Pierre Pelissier, Danielle Ibarrola, Rolf A. Heckemann, Anna Castrioto, Lèon Tremblay, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
    Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease
    Movement Disorders, 1644--1654, Vol: 34, (2019), doi: 10.1002/mds.27793
  • Eva Martinez, Benjamin Pasquereau, Yosuke Saga, Èlise Mètèreau, Lèon Tremblay
    The Anterior Caudate Nucleus Supports Impulsive Choices Triggered by Pramipexole
    Movement Disorders, 296--305, Vol: 35, (2019), doi: 10.1002/mds.27898
  • Maude Beaudoin-Gobert, Elise Mètèreau, Sandra Duperrier, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato
    Pathophysiology of levodopa-induced dyskinesia: Insights from multimodal imaging and immunohistochemistry in non-human primates
    NeuroImage, 132--141, Vol: 183, (2018), doi: 10.1016/j.neuroimage.2018.08.016
  • Vèronique Sgambato, Lèon Tremblay
    Pathophysiology of dyskinesia and behavioral disorders in non-human primates: the role of serotonergic fibers
    Journal of Neural Transmission, 1145--1156, Vol: 125, (2018), doi: 10.1007/s00702-018-1871-7
  • Stèphane Prange, Javier Pagonabarraga, Paul Krack, Jaime Kulisevsky, Vèronique Sgambato, Lèon Tremblay, Stèphane Thobois, Emmanuel Broussolle
    Historical crossroads in the conceptual delineation of apathy in Parkinson's disease
    Brain, 613--619, Vol: 141, (2018), doi: 10.1093/brain/awx362
  • Howard C. Cromwell, Leon Tremblay, Wolfram Schultz
    Neural encoding of choice during a delayed response task in primate striatum and orbitofrontal cortex
    Experimental Brain Research, 1679--1688, Vol: 236, (2018), doi: 10.1007/s00221-018-5253-z
  • Yosuke Saga, Christian C. Ruff, Lèon Tremblay
    Disturbance of approach-avoidance behaviors in non-human primates by stimulation of the limbic territories of basal ganglia and anterior insula
    European Journal of Neuroscience, 687--700, Vol: 49, (2018), doi: 10.1111/ejn.14201
  • Elise Mètèreau, Maude Beaudoin-Gobert, Sandra Duperrier, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato-Faure
    Diffusion tensor imaging marks dopaminergic and serotonergic lesions in the Parkinsonian monkey
    Movement Disorders, 298--309, Vol: 33, (2017), doi: 10.1002/mds.27201
  • Stephane Thobois, Stephane Prange, Vèronique Sgambato-Faure, Lèon Tremblay, Emmanuel Broussolle
    Imaging the Etiology of Apathy, Anxiety, and Depression in Parkinson's Disease: Implication for Treatment
    Current Neurology and Neuroscience Reports, Vol: 17, (2017), doi: 10.1007/s11910-017-0788-0
  • Yosuke Saga, Eiji Hoshi, Lèon Tremblay
    Roles of Multiple Globus Pallidus Territories of Monkeys and Humans in Motivation, Cognition and Action: An Anatomical, Physiological and Pathophysiological Review
    Frontiers in Neuroanatomy, Vol: 11, (2017), doi: 10.3389/fnana.2017.00030
  • Audrey Maillet, Paul Krack, Eugènie Lhommèe, Elise Mètèreau, Hèléne Klinger, Emilie Favre, Didier Le Bars, Emmanuelle Schmitt, Amèlie Bichon, Pierre Pelissier, Valèrie Fraix, Anna Castrioto, Vèronique Sgambato-Faure, Emmanuel Broussolle, Lèon Tremblay, Stèphane Thobois
    The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease
    Brain, 2486--2502, Vol: 139, (2016), doi: 10.1093/brain/aww162
  • Yosuke Saga, Yoshihisa Nakayama, Ken-ichi Inoue, Tomoko Yamagata, Masashi Hashimoto, Lèon Tremblay, Masahiko Takada, Eiji Hoshi
    Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus
    European Journal of Neuroscience, 1186--1199, Vol: 45, (2016), doi: 10.1111/ejn.13421
  • Benedicte Ballanger, Maude Beaudoin-Gobert, Sara Neumane, Justine Epinat, Elise Metereau, Sandra Duperrier, Emmanuel Broussolle, Stephane Thobois, Frederic Bonnefoi, Christian Tourvielle, Franck Lavenne, Nicolas Costes, Didier Lebars, Luc Zimmer, Vèronique Sgambato-Faure, Lèon Tremblay
    Imaging Dopamine and Serotonin Systems on MPTP Monkeys: A Longitudinal PET Investigation of Compensatory Mechanisms
    The Journal of Neuroscience, 1577--1589, Vol: 36, (2016), doi: 10.1523/jneurosci.2010-15.2016
  • Yosuke Saga, Augustin Richard, Vèronique Sgambato-Faure, Eiji Hoshi, Philippe N. Tobler, Lèon Tremblay
    Ventral Pallidum Encodes Contextual Information and Controls Aversive Behaviors
    Cerebral Cortex, bhw107, (2016), doi: 10.1093/cercor/bhw107
  • Maude Beaudoin-Gobert, Justine Epinat, Elise Mètèreau, Sandra Duperrier, Sara Neumane, Bènèdicte Ballanger, Franck Lavenne, François Liger, Christian Tourvielle, Frèdèric Bonnefoi, Nicolas Costes, Didier Le Bars, Emmanuel Broussolle, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato-Faure
    Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate
    Brain, 2632--2647, Vol: 138, (2015), doi: 10.1093/brain/awv183
  • Elodie Durand, Odile Petit, Léon Tremblay, Cédric Zimmer, Véronique Sgambato-Faure, Carine Chassain, Marlène Laurent, Bruno Pereira, Céline Silberberg, Franck Durif
    Social behavioral changes in MPTP-treated monkey model of Parkinson's disease
    Frontiers in Behavioral Neuroscience, Vol: 9, (2015), doi: 10.3389/fnbeh.2015.00042
  • Vèronique Sgambato-Faure, Yulia Worbe, Justine Epinat, Jean Fèger, Lèon Tremblay
    Cortico-basal ganglia circuits involved in different motivation disorders in non-human primates
    Brain Structure and Function, 345--364, Vol: 221, (2014), doi: 10.1007/s00429-014-0911-9
  • Bènèdicte Ballanger, Lèon Tremblay, Vèronique Sgambato-Faure, Maude Beaudoin-Gobert, Franck Lavenne, Didier Le Bars, Nicolas Costes
    A multi-atlas based method for automated anatomical Macaca fascicularis brain MRI segmentation and PET kinetic extraction
    NeuroImage, 26--43, Vol: 77, (2013), doi: 10.1016/j.neuroimage.2013.03.029
  • Yulia Worbe, Vèronique Sgambato-Faure, Justine Epinat, Marion Chaigneau, Dominique Tandè, Chantal François, Jean Fèger, Lèon Tremblay
    Towards a primate model of Gilles de la Tourette syndrome: Anatomo-behavioural correlation of disorders induced by striatal dysfunction
    Cortex, 1126--1140, Vol: 49, (2013), doi: 10.1016/j.cortex.2012.08.020

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