Jean-Claude Dreher (Principal Investigator)

Email: dreher@isc.cnrs.fr
Phone: (334) 37 91 12 38

I am the research director of the ‘Neuroeconomics, Reward and Decision Making’ team (CNRS, France). My background is in Mathematics (master) and Cognitive Neuroscience (Ph.D), which I studied in Paris (University Paris VI and Paris XI). I was subsequently trained in neuroeconomics and neuroimaging as a post-doctoral fellow at the National Institutes of Health (USA), where I conducted research on the neural mechanisms underlying cognitive control, decision making, reward and motivational processes. Since then, I focus on the neural mechanisms underlying value-based decision making in individuals and in social contexts. In 2004, I integrated the CNRS as a research scientist (tenured position) (ranked nº1 at the national level in the Neuroscience Section).

     My goal is to build neurally informed neurocomputational models of human decision-making that explain differences in people’s choice behaviors (e.g. dietary, consumer, social or moral choices). To this end, my research draws on insights and methods from psychology, model-based fMRI and behavioral economics. To understand the neural mechanism that underly our decisions, I use computational models (e.g. machine learning) together with data collected in experiments using fMRI, MEG and intra-cranial recordings in humans. There is a need for building an integrative account of how motivation/emotions and decision processes interact, bridging the gap between fundamental computational principles and the brain system level. This approach should establish a mechanistic foundation for understanding disorders affecting motivation and decision making processes.

Papers

• Rèmi Philippe, Rèmi Janet, Koosha Khalvati, Rajesh Rao, Daeyeol Lee, Jean-Claude Dreher
  Neurocomputational mechanisms engaged in detecting cooperative and competitive intentions of others
  Nature Communications, In Press, (2024), doi: 10.21203/rs.3.rs-1160167/v1
• Yang Hu, Rèmi Philippe, Valentin Guigon, Sasa Zhao, Edmund Derrington, Brice Corgnet, James J. Bonaiuto, Jean-Claude Dreher
  Perturbation of Right Dorsolateral Prefrontal Cortex Makes Power Holders Less Resistant to Tempting Bribes
  Psychological Science, 412--423, Vol: 33, (2022), doi: 10.1177/09567976211042379
• Remi Janet, Romain Ligneul, Annabel B. Losecaat-Vermeer, Remi Philippe, Gabriele Bellucci, Edmund Derrington, Soyoung Q. Park, Jean-Claude Dreher
  Regulation of social hierarchy learning by serotonin transporter availability
  Neuropsychopharmacology, 2205--2212, Vol: 47, (2022), doi: 10.1038/s41386-022-01378-2
• Chen Qu, Julien Bènistant, Jean-Claude Dreher
  Neurocomputational mechanisms engaged in moral choices and moral learning
  Neuroscience and Biobehavioral Reviews, 50--60, Vol: 132, (2022), doi: 10.1016/j.neubiorev.2021.11.023
• Yang Hu, Chen Hu, Edmund Derrington, Brice Corgnet, Chen Qu, Jean-Claude Dreher
  Neural basis of corruption in power-holders
  eLife, Vol: 10, (2021), doi: 10.7554/elife.63922
• Seongmin A. Park, Mariateresa Sestito, Erie D. Boorman, Jean-Claude Dreher
  Neural computations underlying strategic social decision-making in groups
  Nature Communications, Vol: 10, (2019), doi: 10.1038/s41467-019-12937-5
• Chen Qu, Elise Mètèreau, Luigi Butera, Marie Claire Villeval, Jean-Claude Dreher
  Neurocomputational mechanisms at play when weighing concerns for extrinsic rewards, moral values, and social image
  PLOS Biology, e3000283, Vol: 17, (2019), doi: 10.1371/journal.pbio.3000283
• Koosha Khalvati, Seongmin A. Park, Saghar Mirbagheri, Remi Philippe, Mariateresa Sestito, Jean-Claude Dreher, Rajesh P. N. Rao
  Modeling other minds: Bayesian inference explains human choices in group decision-making
  Science Advances, eaax8783, Vol: 5, (2019), doi: 10.1126/sciadv.aax8783
• Romuald Girard, Ignacio Obeso, Stèphane Thobois, Seongmin A Park, Tiphaine Vidal, Emilie Favre, Miguel Ulla, Emmanuel Broussolle, Paul Krack, Franck Durif, Jean-Claude Dreher
  Wait and you shall see: sexual delay discounting in hypersexual Parkinson's disease
  Brain, 146--162, Vol: 142, (2018), doi: 10.1093/brain/awy298
• Ignacio Obeso, Marius Moisa, Christian C Ruff, Jean-Claude Dreher
  A causal role for right temporo-parietal junction in signaling moral conflict
  eLife, Vol: 7, (2018), doi: 10.7554/elife.40671
• Chen Qu, Romain Ligneul, Jean-Baptiste Van der Henst, Jean-Claude Dreher
  An Integrative Interdisciplinary Perspective on Social Dominance Hierarchies
  Trends in Cognitive Sciences, 893--908, Vol: 21, (2017), doi: 10.1016/j.tics.2017.08.004
• Seongmin A. Park, Sidney Goïame, David A. O'Connor, Jean-Claude Dreher
  Integration of individual and social information for decision-making in groups of different sizes
  PLOS Biology, e2001958, Vol: 15, (2017), doi: 10.1371/journal.pbio.2001958
• Jean-Claude Dreher, Simon Dunne, Agnieszka Pazderska, Thomas Frodl, John J. Nolan, John P. O'Doherty
  Testosterone causes both prosocial and antisocial status-enhancing behaviors in human males
  Proceedings of the National Academy of Sciences, 11633--11638, Vol: 113, (2016), doi: 10.1073/pnas.1608085113
• Romain Ligneul, Ignacio Obeso, Christian C. Ruff, Jean-Claude Dreher
  Dynamical Representation of Dominance Relationships in the Human Rostromedial Prefrontal Cortex
  Current Biology, 3107--3115, Vol: 26, (2016), doi: 10.1016/j.cub.2016.09.015
• Yansong Li, Giovanna Vanni-Mercier, Jean Isnard, François Mauguiére, Jean-Claude Dreher
  The neural dynamics of reward value and risk coding in the human orbitofrontal cortex
  Brain, 1295--1309, Vol: 139, (2016), doi: 10.1093/brain/awv409
• Guillaume Sescousse, Guillaume Barbalat, Philippe Domenech, Jean-Claude Dreher
  Imbalance in the sensitivity to different types of rewards in pathological gambling
  Brain, 2527--2538, Vol: 136, (2013), doi: 10.1093/brain/awt126
• Guillaume Sescousse, Xavier Caldù, Bárbara Segura, Jean-Claude Dreher
  Processing of primary and secondary rewards: A quantitative meta-analysis and review of human functional neuroimaging studies
  Neuroscience & Biobehavioral Reviews, 681--696, Vol: 37, (2013), doi: 10.1016/j.neubiorev.2013.02.002
• Jean-Claude Dreher, Paul Koch, Philip Kohn, Jose Apud, Daniel R. Weinberger, Karen Faith Berman
  Common and Differential Pathophysiological Features Accompany Comparable Cognitive Impairments in Medication-Free Patients with Schizophrenia and in Healthy Aging Subjects
  Biological Psychiatry, 890--897, Vol: 71, (2012), doi: 10.1016/j.biopsych.2012.01.002
• J.-C. Dreher, P. Kohn, B. Kolachana, D. R. Weinberger, K. F. Berman
  Variation in dopamine genes influences responsivity of the human reward system
  Proceedings of the National Academy of Sciences, 617--622, Vol: 106, (2008), doi: 10.1073/pnas.0805517106
• J.-C. Dreher, A. Meyer-Lindenberg, P. Kohn, K. F. Berman
  Age-related changes in midbrain dopaminergic regulation of the human reward system
  Proceedings of the National Academy of Sciences, 15106--15111, Vol: 105, (2008), doi: 10.1073/pnas.0802127105
• J.-C. Dreher, P. J. Schmidt, P. Kohn, D. Furman, D. Rubinow, K. F. Berman
  Menstrual cycle phase modulates reward-related neural function in women
  Proceedings of the National Academy of Sciences, 2465--2470, Vol: 104, (2007), doi: 10.1073/pnas.0605569104
• J.-C. Dreher, K. F. Berman
  Fractionating the neural substrate of cognitive control processes
  Proceedings of the National Academy of Sciences, 14595--14600, Vol: 99, (2002), doi: 10.1073/pnas.222193299