Stéphane Thobois

Email: stephane.thobois@chu-lyon.fr
Phone: +33 (0)4 72 35 72 18

Papers

• Chloè Laurencin, Noèmie Timestit, Ana Marques, Domitille Dilly Duchez, Caroline Giordana, Sara Meoni, Marine Huddlestone, Teodor Danaila, Mathieu Anheim, Hèléne Klinger, Tiphaine Vidal, Marion Fatisson, Catherine Caire, Mikail Nourredine, Philippe Boulinguez, Carole Dhelens, Bènèdicte Ballanger, Stèphane Prange, Sylvie Bin, Stèphane Thobois
  Efficacy and safety of clonidine for the treatment of impulse control disorder in Parkinson's disease: a multicenter, parallel, randomised, double-blind, Phase 2b Clinical trial
  Journal of Neurology, (2023), doi: 10.1007/s00415-023-11814-y
• Laila Khedher, Jean-Marie Bonny, Ana Marques, Elodie Durand, Bruno Pereira, Marie Chupin, Tiphaine Vidal, Carine Chassain, Luc Defebvre, Nicolas Carriere, Valerie Fraix, Elena Moro, Stèphane Thobois, Elise Metereau, Franck Durif
  Intrasubject subcortical quantitative referencing to boost MRI sensitivity to Parkinson's disease
  NeuroImage: Clinical, 103231, Vol: 36, (2022), doi: 10.1016/j.nicl.2022.103231
• Guillaume Petit, Paul Jaulent, Eduardo Couchonnal-Bedoya, Olivier Guillaud, Stèphane Thobois, Chloè Laurencin
  Polydipsia: An atypical symptom of Wilson disease
  Revue Neurologique, 394--395, Vol: 178, (2022), doi: 10.1016/j.neurol.2021.09.007
• Stèphane Prange, Hèléne Klinger, Chloè Laurencin, Teodor Danaila, Stèphane Thobois
  Depression in Patients with Parkinson's Disease: Current Understanding of its Neurobiology and Implications for Treatment
  Drugs & Aging, 417--439, Vol: 39, (2022), doi: 10.1007/s40266-022-00942-1
• Stèphane Prange, Elise Metereau, Audrey Maillet, Hèléne Klinger, Emmanuelle Schmitt, Eugènie Lhommèe, Amèlie Bichon, Sophie Lancelot, Sara Meoni, Emmanuel Broussolle, Anna Castrioto, Lèon Tremblay, Paul Krack, Stèphane Thobois
  Limbic Serotonergic Plasticity Contributes to the Compensation of Apathy in Early Parkinson's Disease
  Movement Disorders, 1211--1221, Vol: 37, (2022), doi: 10.1002/mds.28971
• Stèphane Prange, Teodor Danaila, Chloè Laurencin, Elise Metereau, Stèphane Thobois et al
  Limbic Stimulation Drives Mania in STN-DBS in Parkinson Disease: A Prospective Study
  Annals of Neurology, 411--417, Vol: 92, (2022), doi: 10.1002/ana.26434
• Audrey Maillet, Elise Mètèreau, Lèon Tremblay, Emilie Favre, Hèléne Klinger, Eugènie Lhommèe, Didier Le Bars, Anna Castrioto, Stèphane Prange, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
  Serotonergic and Dopaminergic Lesions Underlying Parkinsonian Neuropsychiatric Signs
  Movement Disorders, 2888--2900, Vol: 36, (2021), doi: 10.1002/mds.28722
• Shams Ribault, Emile Simon, Julien Berthiller, Gustavo Polo, Adèlaïde Nunes, Andrei Brinzeu, Patrick Mertens, Teodor Danaila, Stèphane Thobois, Chloè Laurencin
  Comparison of clinical outcomes and accuracy of electrode placement between robot-assisted and conventional deep brain stimulation of the subthalamic nucleus: a single-center study
  Acta Neurochirurgica, 1327--1333, Vol: 163, (2021), doi: 10.1007/s00701-021-04790-7
• T. Wirth, C. Laurencin, J. Berthillier, A. Brinzeu, G. Polo, E. Simon, P. Mertens, E. Broussolle, T. Danaila, S. Thobois
  Feasibility of changing for a rechargeable constant current neurostimulator in Parkinson's disease
  Revue Neurologique, 283--289, Vol: 177, (2021), doi: 10.1016/j.neurol.2020.02.007
• Suzanne Lesage, Marion Houot, Graziella Mangone, Christelle Tesson, Hèléne Bertrand, Sylvie Forlani, Mathieu Anheim, Christine Brefel-Courbon, Emmanuel Broussolle, Stèphane Thobois, Philippe Damier, Franck Durif
  Genetic and Phenotypic Basis of Autosomal Dominant Parkinson's Disease in a Large Multi-Center Cohort
  Frontiers in Neurology, Vol: 11, (2020), doi: 10.3389/fneur.2020.00682
• Graziella Mangone, Samir Bekadar, Florence Cormier-Dequaire, Khadija Tahiri, Arlette Welaratne, Virginie Czernecki, Fanny Pineau, Carine Karachi, Anna Castrioto, Frank Durif, Christine Tranchant, David Devos, Stèphane Thobois
  Early cognitive decline after bilateral subthalamic deep brain stimulation in Parkinson's disease patients with GBA mutations
  Parkinsonism & Related Disorders, 56--62, Vol: 76, (2020), doi: 10.1016/j.parkreldis.2020.04.002
• Stèphane Prange, Elise Metereau, Audrey Maillet, Eugènie Lhommèe, Hèléne Klinger, Pierre Pelissier, Danielle Ibarrola, Rolf A. Heckemann, Anna Castrioto, Lèon Tremblay, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
  Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease
  Movement Disorders, 1644--1654, Vol: 34, (2019), doi: 10.1002/mds.27793
• K. Knudsen, P. Krack, L. Tonder, J.-L. Houeto, J. Rau, C. Schade-Brittinger, A. Hartmann, Thomas D. Hälbig, Stephen Paschen, Michael T. Barbe, Andrea Kühn, Valerie Fraix, Christine Brefel-Courbon, Jan Vesper, David Maltête, Friederike Sixel-Döring, Daniel Weiss, Tatiana Witjas, Stephane Thobois, Yves Agid, A. Schnitzler, W.M.M. Schuepbach, L. Timmermann, Philippe Damier, M. Vidailhet, G. Deuschl
  Programming parameters of subthalamic deep brain stimulators in Parkinson's disease from a controlled trial
  Parkinsonism & Related Disorders, 217--223, Vol: 65, (2019), doi: 10.1016/j.parkreldis.2019.05.023
• Chloè Laurencin, Emmanuel Broussolle, Teodor Danaila, Mathieu Anheim, Jamel Chelly, Stephane Thobois
  A novel heterozygous ANO3 mutation responsible for myoclonic dystonia
  Journal of the Neurological Sciences, 65--66, Vol: 403, (2019), doi: 10.1016/j.jns.2019.06.014
• Stèphane Prange, Elise Metereau, Stèphane Thobois
  Structural Imaging in Parkinson's Disease: New Developments
  Current Neurology and Neuroscience Reports, Vol: 19, (2019), doi: 10.1007/s11910-019-0964-5
• Stèphane Thobois, Stèphane Prange, Christian Scheiber, Emmanuel Broussolle
  What a neurologist should know about PET and SPECT functional imaging for parkinsonism: A practical perspective
  Parkinsonism & Related Disorders, 93--100, Vol: 59, (2019), doi: 10.1016/j.parkreldis.2018.08.016
• Maude Beaudoin-Gobert, Elise Mètèreau, Sandra Duperrier, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato
  Pathophysiology of levodopa-induced dyskinesia: Insights from multimodal imaging and immunohistochemistry in non-human primates
  NeuroImage, 132--141, Vol: 183, (2018), doi: 10.1016/j.neuroimage.2018.08.016
• Stephane Thobois, Christine Brefel-Courbon, Didier Le Bars, Vèronique Sgambato-Faure
  Molecular Imaging of Opioid System in Idiopathic Parkinson's Disease
  275--303, (2018), doi: 10.1016/bs.irn.2018.07.029
• Stèphane Prange, Javier Pagonabarraga, Paul Krack, Jaime Kulisevsky, Vèronique Sgambato, Lèon Tremblay, Stèphane Thobois, Emmanuel Broussolle
  Historical crossroads in the conceptual delineation of apathy in Parkinson's disease
  Brain, 613--619, Vol: 141, (2018), doi: 10.1093/brain/awx362
• Marie Abbes, Eugènie Lhommèe, Stèphane Thobois, Hèléne Klinger, Emmanuelle Schmitt, Amèlie Bichon, Anna Castrioto, Jing Xie, Valèrie Fraix, Andrea Kistner, Pierre Pèlissier, Èric Seigneuret, Stèphan Chabardés, Patrick Mertens, Emmanuel Broussolle, Elena Moro, Paul Krack
  Subthalamic stimulation and neuropsychiatric symptoms in Parkinson's disease: results from a long-term follow-up cohort study
  Journal of Neurology, Neurosurgery & Psychiatry, 836--843, Vol: 89, (2018), doi: 10.1136/jnnp-2017-316373
• Marie Coutelier, Monia B. Hammer, Giovanni Stevanin, Marie-Lorraine Monin, Claire-Sophie Davoine, Fanny Mochel, Pierre Labauge, Claire Ewenczyk, Jinhui Ding, J. Raphael Gibbs, Didier Hannequin, Judith Melki, Annick Toutain, Vincent Laugel, Sylvie Forlani, Perrine Charles, Emmanuel Broussolle, Stèphane Thobois et al
  Efficacy of Exome-Targeted Capture Sequencing to Detect Mutations in Known Cerebellar Ataxia Genes
  JAMA Neurology, 591, Vol: 75, (2018), doi: 10.1001/jamaneurol.2017.5121
• Romuald Girard, Ignacio Obeso, Stèphane Thobois, Seongmin A Park, Tiphaine Vidal, Emilie Favre, Miguel Ulla, Emmanuel Broussolle, Paul Krack, Franck Durif, Jean-Claude Dreher
  Wait and you shall see: sexual delay discounting in hypersexual Parkinson's disease
  Brain, 146--162, Vol: 142, (2018), doi: 10.1093/brain/awy298
• Chloe Laurencin, Solveig Montaut, Christophe Vial, Lorraine Bernard, Sylvie Bin, Lucie Rascle, Gustavo Polo, Patrick Mertens, Teodor Danaila, Stephane Thobois
  Toe dystonia in Parkinson's disease: Impact of subthalamic nucleus deep brain stimulation
  Journal of the Neurological Sciences, 65--68, Vol: 392, (2018), doi: 10.1016/j.jns.2018.07.004
• Eugènie Lhommèe, Lars Wojtecki, Virginie Czernecki, Karsten Witt, Franziska Maier, Lisa Tonder, Lars Timmermann, Thomas D Hälbig, Fanny Pineau, Franck Durif, Tatiana Witjas, Marcus Pinsker, Maximilian Mehdorn, Friederike Sixel-Döring, Andreas Kupsch, Rejko Krüger, Saskia Elben, Stephan Chabardés, Stèphane Thobois et al
  Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial
  The Lancet Neurology, 223--231, Vol: 17, (2018), doi: 10.1016/s1474-4422(18)30035-8
• Stèphane Prange, Teodor Danaila, Chloè Laurencin, Catherine Caire, Elise Metereau, Hèléne Merle, Emmanuel Broussolle, Delphine Maucort-Boulch, Stèphane Thobois
  Age and time course of long-term motor and nonmotor complications in Parkinson disease
  Neurology, e148--e160, Vol: 92, (2018), doi: 10.1212/wnl.0000000000006737
• Emmanuelle Schmitt, Paul Krack, Anna Castrioto, Helene Klinger, Amelie Bichon, Eugènie Lhommèe, Pierre Pelissier, Valerie Fraix, Stephane Thobois, Elena Moro, Pablo Martinez-Martin
  The Neuropsychiatric Fluctuations Scale for Parkinson's Disease: A Pilot Study
  Movement Disorders Clinical Practice, 265--272, Vol: 5, (2018), doi: 10.1002/mdc3.12607
• Elise Mètèreau, Maude Beaudoin-Gobert, Sandra Duperrier, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato-Faure
  Diffusion tensor imaging marks dopaminergic and serotonergic lesions in the Parkinsonian monkey
  Movement Disorders, 298--309, Vol: 33, (2017), doi: 10.1002/mds.27201
• Benoit Delpont, Eugènie Lhommèe, Hèléne Klinger, Emmanuelle Schmitt, Amèlie Bichon, Valèrie Fraix, Anna Castrioto, Jean-Louis Quesada, Pierre Pèlissier, Andrea Kistner, Sèbastien Carnicella, Christian Lüscher, Emmanuel Broussolle, Pierre Pollak, Stèphane Thobois, Paul Krack
  Psychostimulant effect of dopaminergic treatment and addictions in Parkinson's disease
  Movement Disorders, 1566--1573, Vol: 32, (2017), doi: 10.1002/mds.27101
• Stephane Thobois, Stephane Prange, Vèronique Sgambato-Faure, Lèon Tremblay, Emmanuel Broussolle
  Imaging the Etiology of Apathy, Anxiety, and Depression in Parkinson's Disease: Implication for Treatment
  Current Neurology and Neuroscience Reports, Vol: 17, (2017), doi: 10.1007/s11910-017-0788-0
• N. J. Thomas, P. Mertens, T. Danaila, G. Polo, H. Klinger, E. Broussolle, S. Thobois
  Optimizing the deep brain stimulation care pathway in patients with Parkinson's disease
  Journal of Neurology, 1454--1464, Vol: 264, (2017), doi: 10.1007/s00415-017-8548-2
• Audrey Maillet, Paul Krack, Eugènie Lhommèe, Elise Mètèreau, Hèléne Klinger, Emilie Favre, Didier Le Bars, Emmanuelle Schmitt, Amèlie Bichon, Pierre Pelissier, Valèrie Fraix, Anna Castrioto, Vèronique Sgambato-Faure, Emmanuel Broussolle, Lèon Tremblay, Stèphane Thobois
  The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease
  Brain, 2486--2502, Vol: 139, (2016), doi: 10.1093/brain/aww162
• Cyril Atkinson-Clement, Audrey Maillet, Didier LeBars, Franck Lavenne, Jèrôme Redoutè, Alexandre Krainik, Pierre Pollak, Stèphane Thobois, Serge Pinto
  Subthalamic nucleus stimulation effects on single and combined task performance in Parkinson's disease patients: a PET study
  Brain Imaging and Behavior, 1139--1153, Vol: 11, (2016), doi: 10.1007/s11682-016-9588-4
• Benedicte Ballanger, Maude Beaudoin-Gobert, Sara Neumane, Justine Epinat, Elise Metereau, Sandra Duperrier, Emmanuel Broussolle, Stephane Thobois, Frederic Bonnefoi, Christian Tourvielle, Franck Lavenne, Nicolas Costes, Didier Lebars, Luc Zimmer, Vèronique Sgambato-Faure, Lèon Tremblay
  Imaging Dopamine and Serotonin Systems on MPTP Monkeys: A Longitudinal PET Investigation of Compensatory Mechanisms
  The Journal of Neuroscience, 1577--1589, Vol: 36, (2016), doi: 10.1523/jneurosci.2010-15.2016
• Anna Castrioto, Stèphane Thobois, Sebastien Carnicella, Audrey Maillet, Paul Krack
  Emotional manifestations of PD: Neurobiological basis
  Movement Disorders, 1103--1113, Vol: 31, (2016), doi: 10.1002/mds.26587
• Marion Criaud, Alice Poisson, Stèphane Thobois, Elise Metereau, Jèrôme Redoutè, Daniéle Ibarrola, Pierre Baraduc, Emmanuel Broussolle, Antonio P. Strafella, Bènèdicte Ballanger, Philippe Boulinguez
  Slowness in Movement Initiation is Associated with Proactive Inhibitory Network Dysfunction in Parkinson's Disease
  Journal of Parkinson's Disease, 433--440, Vol: 6, (2016), doi: 10.3233/jpd-150750
• C. Laurencin, T. Danaila, E. Broussolle, S. Thobois
  Initial treatment of Parkinson's disease in 2016: The 2000 consensus conference revisited
  Revue Neurologique, 512--523, Vol: 172, (2016), doi: 10.1016/j.neurol.2016.07.007
• Maude Beaudoin-Gobert, Justine Epinat, Elise Mètèreau, Sandra Duperrier, Sara Neumane, Bènèdicte Ballanger, Franck Lavenne, François Liger, Christian Tourvielle, Frèdèric Bonnefoi, Nicolas Costes, Didier Le Bars, Emmanuel Broussolle, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato-Faure
  Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate
  Brain, 2632--2647, Vol: 138, (2015), doi: 10.1093/brain/awv183
• Audrey Maillet, Stèphane Thobois, Valèrie Fraix, Jèrôme Redoutè, Didier Le Bars, Franck Lavenne, Philippe Derost, Franck Durif, Bastiaan R. Bloem, Paul Krack, Pierre Pollak, Bettina Debû
  Neural substrates of levodopa-responsive gait disorders and freezing in advanced Parkinson's disease: A kinesthetic imagery approach
  Human Brain Mapping, 959--980, Vol: 36, (2014), doi: 10.1002/hbm.22679