Véronique Sgambato (Principal Investigator)

Email: veronique.sgambato@inserm.fr
Phone: (334) 37 91 12 49

Véronique Sgambato is a neurobiologist (Researcher ID: G-9062-2017; ORCID: 0000-0002-8792-8586). She obtained her PhD in Neuroscience in 1998 from the University Pierre et Marie Curie in Paris (Ph.D. director Prof. Jean-Michel Deniau; Laboratory of Neuroanatomy and Neurochemistry headed by Prof. Marie-Jo Besson). After two postdoctoral trainings in the USA in the laboratories of Prof. Steven E. Hyman (Molecular Plasticity Section, NINDS, NIH, Bethesda, MD) and of Prof. Paul Greengard (Nobel Prize in Medicine in 2000; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New-York City), she got an academic position in 2002 as a research scientist at INSERM, the French National Institute of Health and Medical Research. From 2003 to 2008, she worked in Grenoble (laboratories of Prof. Alim-Louis Benabid, INSERM U318 Preclinical Neuroscience and then of Dr. Marc Savasta, Grenoble Institute of Neuroscience) to investigate the impact of deep brain stimulation and levodopa treatment, the two major symptomatic treatments for Parkinson’s disease (PD), on the plasticity of basal ganglia neurons by combining behavioral, biochemical and immunohistochemical approaches on rodent models. In 2009, she moved to Lyon to join the Institute of cognitive Sciences Marc Jeannerod (Mixt Research Unit 5229 from the Scientific Research National Center (CNRS) and University of Lyon 1) and focused her research on the role of the serotonergic system in the pathophysiology of motor and non-motor symptoms in PD by combining behavioral, imaging and anatomical approaches on primates. Since January 1st, 2021, she leads a research team entitled “Neuroplasticity in Parkinson’s disease”. Dr Sgambato was President of the French basal ganglia club from june 2018 to january 2023. She is actually member of scientific committee of France Parkinson and associate editor for Nature Journal of Parkinson's disease. Dr Sgambato’s work is supported by the CNRS, Université de Lyon, Fondation de France, Fondation Neurodis, France Parkinson and Agence Nationale de la Recherche.

Papers

• Rubèn Pavia-Collado, Raquel Rodr'iguez-Aller, Diana Alarcòn-Ar'is, Llu'is Miquel-Rio, Esther Ruiz-Bronchal, Verònica Paz, Leticia Campa, Mireia Galofrè, Vèronique Sgambato, Analia Bortolozzi
  Up and Down $upgamma$-Synuclein Transcription in Dopamine Neurons Translates into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice
  International Journal of Molecular Sciences, 1807, Vol: 23, (2022), doi: 10.3390/ijms23031807
• Sandra Duperrier, Analia Bortolozzi, Vèronique Sgambato
  Increased Expression of Alpha-, Beta-, and Gamma-Synucleins in Brainstem Regions of a Non-Human Primate Model of Parkinson's Disease
  International Journal of Molecular Sciences, 8586, Vol: 23, (2022), doi: 10.3390/ijms23158586
• Audrey Maillet, Elise Mètèreau, Lèon Tremblay, Emilie Favre, Hèléne Klinger, Eugènie Lhommèe, Didier Le Bars, Anna Castrioto, Stèphane Prange, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
  Serotonergic and Dopaminergic Lesions Underlying Parkinsonian Neuropsychiatric Signs
  Movement Disorders, 2888--2900, Vol: 36, (2021), doi: 10.1002/mds.28722
• Benjamin Pasquereau, Guillaume Drui, Yosuke Saga, Augustin Richard, Mathilde Millot, Elise Mètèreau, Vèronique Sgambato, Philippe N. Tobler, Lèon Tremblay
  Selective serotonin reuptake inhibitor treatment retunes emotional valence in primate ventral striatum
  Neuropsychopharmacology, 2073--2082, Vol: 46, (2021), doi: 10.1038/s41386-021-00991-x
• David Mallet, Thibault Dufourd, Mèlina Decourt, Carole Carcenac, Paola Bossú, Laure Verlin, Pierre-Olivier Fernagut, Marianne Benoit-Marand, Gianfranco Spalletta, Emmanuel L. Barbier, Sebastien Carnicella, Vèronique Sgambato, Florence Fauvelle, Sabrina Boulet
  A metabolic biomarker for early stage of Parkinson's disease in patients and animal models
  Journal of Clinical Investigation, (2021), doi: 10.1172/jci146400
• Cristina Miguelez, Philippe De Deurwaerdére, Vèronique Sgambato
  Editorial: Non-Dopaminergic Systems in Parkinson's Disease
  Frontiers in Pharmacology, Vol: 11, (2020), doi: 10.3389/fphar.2020.593822
• Kathy Dujardin, Vèronique Sgambato
  Neuropsychiatric Disorders in Parkinson's Disease: What Do We Know About the Role of Dopaminergic and Non-dopaminergic Systems?
  Frontiers in Neuroscience, Vol: 14, (2020), doi: 10.3389/fnins.2020.00025
• Mathilde Millot, Yosuke Saga, Sandra Duperrier, Elise Mètèreau, Maude Beaudoin-Gobert, Vèronique Sgambato
  Prior MDMA administration aggravates MPTP-induced Parkinsonism in macaque monkeys
  Neurobiology of Disease, 104643, Vol: 134, (2020), doi: 10.1016/j.nbd.2019.104643
• Vèronique Sgambato
  Blood Flow as a Route for Bidirectional Propagation of Synucleinopathy in Parkinson's Disease?
  Movement Disorders, 1751--1751, Vol: 35, (2020), doi: 10.1002/mds.28236
• Sgambato V.
  Breathing new life into neurotoxic-based monkey models of Parkinson's disease to study the complex biological interplay between serotonin and dopamine. In: 5-HT interaction with other neurotransmitters: experimental evidence and therapeutic relevance (Di Giovanni G and De Deurwaeredere P, Eds)
  Progress in Brain Research, (2020)
• Stèphane Prange, Elise Metereau, Audrey Maillet, Eugènie Lhommèe, Hèléne Klinger, Pierre Pelissier, Danielle Ibarrola, Rolf A. Heckemann, Anna Castrioto, Lèon Tremblay, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
  Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease
  Movement Disorders, 1644--1654, Vol: 34, (2019), doi: 10.1002/mds.27793
• Maude Beaudoin-Gobert, Elise Mètèreau, Sandra Duperrier, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato
  Pathophysiology of levodopa-induced dyskinesia: Insights from multimodal imaging and immunohistochemistry in non-human primates
  NeuroImage, 132--141, Vol: 183, (2018), doi: 10.1016/j.neuroimage.2018.08.016
• Stephane Thobois, Christine Brefel-Courbon, Didier Le Bars, Vèronique Sgambato-Faure
  Molecular Imaging of Opioid System in Idiopathic Parkinson's Disease
  275--303, (2018), doi: 10.1016/bs.irn.2018.07.029
• Vèronique Sgambato, Lèon Tremblay
  Pathophysiology of dyskinesia and behavioral disorders in non-human primates: the role of serotonergic fibers
  Journal of Neural Transmission, 1145--1156, Vol: 125, (2018), doi: 10.1007/s00702-018-1871-7
• Stèphane Prange, Javier Pagonabarraga, Paul Krack, Jaime Kulisevsky, Vèronique Sgambato, Lèon Tremblay, Stèphane Thobois, Emmanuel Broussolle
  Historical crossroads in the conceptual delineation of apathy in Parkinson's disease
  Brain, 613--619, Vol: 141, (2018), doi: 10.1093/brain/awx362
• Elise Mètèreau, Maude Beaudoin-Gobert, Sandra Duperrier, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato-Faure
  Diffusion tensor imaging marks dopaminergic and serotonergic lesions in the Parkinsonian monkey
  Movement Disorders, 298--309, Vol: 33, (2017), doi: 10.1002/mds.27201
• Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut
  Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update
  The Lancet Neurology, 238--250, Vol: 16, (2017), doi: 10.1016/s1474-4422(17)30004-2
• Audrey Maillet, Paul Krack, Eugènie Lhommèe, Elise Mètèreau, Hèléne Klinger, Emilie Favre, Didier Le Bars, Emmanuelle Schmitt, Amèlie Bichon, Pierre Pelissier, Valèrie Fraix, Anna Castrioto, Vèronique Sgambato-Faure, Emmanuel Broussolle, Lèon Tremblay, Stèphane Thobois
  The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson's disease
  Brain, 2486--2502, Vol: 139, (2016), doi: 10.1093/brain/aww162
• Maude Beaudoin-Gobert, Justine Epinat, Elise Mètèreau, Sandra Duperrier, Sara Neumane, Bènèdicte Ballanger, Franck Lavenne, François Liger, Christian Tourvielle, Frèdèric Bonnefoi, Nicolas Costes, Didier Le Bars, Emmanuel Broussolle, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato-Faure
  Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate
  Brain, 2632--2647, Vol: 138, (2015), doi: 10.1093/brain/awv183