Teams
Brain Imaging Methodological Axis
(PI: Bassem Hiba)
The aim of this axis is to develop and set-up advanced acquisition and post-processing methods for human and non-human primate brain imaging. We will focus our efforts on the development of high-resolution brain MRI pulse-sequences which are presently a crucial issue for medical applications and for neuroscience research. To reach this objective, we developed a high sensitivity MRI pulse sequences based on a 3D-sampling of Fourier-space.
![](http://www.isc.cnrs.fr/photo/p549a6f05cc31ab2309d5ba1f0523ef23.jpg)
The long acquisition duration and the vulnerability to head motion limits the feasibility of brain high-resolution MRI and particularly for young children and for patients with heavy daises. To overcome these limitations, MRI pulse-sequences based on a 3D-sampling of Fourier-space are combined to appropriated strategies of head-motions compensation.
The developed methods will be used for
- Cross-species studies of brain connectivity in collaboration with Angela Sirigu's team.
- Multimodal studies of brain connectivity by tractography and direct cortical stimulation in the operating room in humans in collaboration with Michel Desmurget's team.
- Precise characterization of brain development of macaques, in collaboration with Pier Francesco Ferrari's team, and of human infants in collaboration with James Bonaiuto’s team.
![](http://www.isc.cnrs.fr/photo/p191e33ec482bf3841d69d090daafe5d4.jpg)
The methodological developments of high spatial resolution MRI is carried out on a 3T MRI (Prisma, SIEMENS) in collaboration with CERMEP (the medical imaging platform in Lyon) and with Siemens Healthcare.
Finally, in collaboration with the IT department of the ISC-MJ (Dr. Nathalie Richard and Mr. Sylvain Maurin), a computationally intensive infrastructure dedicated to the reconstruction and post-processing of high-resolution MRI data has been set up.
The team also has high level expertise in ex-vivo MRI of the fixed brain.
Recently and in collaboration with the team of Dr. James Bonaiuto, the team has implemented real-time head movement compensation methods to obtain artefact-free high-resolution MRI in babies as young as 3 months without anaesthesia
![](http://www.isc.cnrs.fr/photo/paf2d9c11926c3a36db448d8b74095a68.jpg)