Teams
Pathophysiology of the Basal Ganglia
(PI: Léon Tremblay)
Our team entitled has been created (2009) following the coming together of researchers and neurologists, around a common research theme which is the pathophysiology of Parkinson’s disease (PD) and more generally the pathophysiology of the Basal ganglia (BG). By combining a preclinical approach, that is developed on non-human primate (NHP), with the clinical approach (based on PET imaging) performed in patients our translational research objectives are focused on three main axis:
- a better understanding the pathophysiology of PD and of compensatory mechanisms taking place after dopamine and serotonin depletion
- a highlighting of the non-motor functions (motivation and cognitive functions) of BG in the context of different Neuropsychiatric disorders such as PD, Tourette’s syndrome, Schizophrenia, compulsive-impulsive disorders, Depression and food intake disorders
- and finally a questioning regarding the impact and mechanisms of therapeutic approaches (Deep brain stimulation, pharmacological approach targeting dopamine and/or serotonin transmission and cognitive remediation) to potentially reverse neuropsychiatric symptoms involving BG dysfunctions.
Selected Papers
- Stèphane Prange, Elise Metereau, Audrey Maillet, Hèléne Klinger, Emmanuelle Schmitt, Eugènie Lhommèe, Amèlie Bichon, Sophie Lancelot, Sara Meoni, Emmanuel Broussolle, Anna Castrioto, Lèon Tremblay, Paul Krack, Stèphane Thobois
Limbic Serotonergic Plasticity Contributes to the Compensation of Apathy in Early Parkinson's Disease
Movement Disorders, 1211--1221, Vol: 37, (2022), doi: 10.1002/mds.28971 - Stèphane Prange, Hèléne Klinger, Chloè Laurencin, Teodor Danaila, Stèphane Thobois
Depression in Patients with Parkinson's Disease: Current Understanding of its Neurobiology and Implications for Treatment
Drugs & Aging, 417--439, Vol: 39, (2022), doi: 10.1007/s40266-022-00942-1 - Stèphane Prange, Elise Metereau, Audrey Maillet, Hèléne Klinger, Emmanuelle Schmitt, Eugènie Lhommèe, Amèlie Bichon, Sophie Lancelot, Sara Meoni, Emmanuel Broussolle, Anna Castrioto, Lèon Tremblay, Paul Krack, Stèphane Thobois
Limbic Serotonergic Plasticity Contributes to the Compensation of Apathy in Early Parkinson's Disease
Movement Disorders, 1211--1221, Vol: 37, (2022), doi: 10.1002/mds.28971 - Stèphane Prange, Elise Metereau, Audrey Maillet, Hèléne Klinger, Emmanuelle Schmitt, Eugènie Lhommèe, Amèlie Bichon, Sophie Lancelot, Sara Meoni, Emmanuel Broussolle, Anna Castrioto, Lèon Tremblay, Paul Krack, Stèphane Thobois
Limbic Serotonergic Plasticity Contributes to the Compensation of Apathy in Early Parkinson's Disease
Movement Disorders, 1211--1221, Vol: 37, (2022), doi: 10.1002/mds.28971 - Yosuke Saga, Laurent Galineau, Lèon Tremblay
Impulsive and compulsive behaviors can be induced by opposite GABAergic dysfunctions inside the primate ventral pallidum
Frontiers in Systems Neuroscience, Vol: 16, (2022), doi: 10.3389/fnsys.2022.1009626 - Audrey Maillet, Elise Mètèreau, Lèon Tremblay, Emilie Favre, Hèléne Klinger, Eugènie Lhommèe, Didier Le Bars, Anna Castrioto, Stèphane Prange, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
Serotonergic and Dopaminergic Lesions Underlying Parkinsonian Neuropsychiatric Signs
Movement Disorders, 2888--2900, Vol: 36, (2021), doi: 10.1002/mds.28722 - Audrey Maillet, Elise Mètèreau, Lèon Tremblay, Emilie Favre, Hèléne Klinger, Eugènie Lhommèe, Didier Le Bars, Anna Castrioto, Stèphane Prange, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
Serotonergic and Dopaminergic Lesions Underlying Parkinsonian Neuropsychiatric Signs
Movement Disorders, 2888--2900, Vol: 36, (2021), doi: 10.1002/mds.28722 - Mathilde Millot, Yosuke Saga, Sandra Duperrier, Elise Mètèreau, Maude Beaudoin-Gobert, Vèronique Sgambato
Prior MDMA administration aggravates MPTP-induced Parkinsonism in macaque monkeys
Neurobiology of Disease, 104643, Vol: 134, (2020), doi: 10.1016/j.nbd.2019.104643 - Eva Martinez, Benjamin Pasquereau, Guillaume Drui, Yosuke Saga, Èlise Mètèreau, Lèon Tremblay
Ventral striatum supports Methylphenidate therapeutic effects on impulsive choices expressed in temporal discounting task
Scientific Reports, Vol: 10, (2020), doi: 10.1038/s41598-020-57595-6 - Eva Martinez, Benjamin Pasquereau, Guillaume Drui, Yosuke Saga, Èlise Mètèreau, Lèon Tremblay
Ventral striatum supports Methylphenidate therapeutic effects on impulsive choices expressed in temporal discounting task
Scientific Reports, Vol: 10, (2020), doi: 10.1038/s41598-020-57595-6 - Stèphane Prange, Elise Metereau, Audrey Maillet, Eugènie Lhommèe, Hèléne Klinger, Pierre Pelissier, Danielle Ibarrola, Rolf A. Heckemann, Anna Castrioto, Lèon Tremblay, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease
Movement Disorders, 1644--1654, Vol: 34, (2019), doi: 10.1002/mds.27793 - Stèphane Prange, Elise Metereau, Audrey Maillet, Eugènie Lhommèe, Hèléne Klinger, Pierre Pelissier, Danielle Ibarrola, Rolf A. Heckemann, Anna Castrioto, Lèon Tremblay, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease
Movement Disorders, 1644--1654, Vol: 34, (2019), doi: 10.1002/mds.27793 - Stèphane Prange, Elise Metereau, Audrey Maillet, Eugènie Lhommèe, Hèléne Klinger, Pierre Pelissier, Danielle Ibarrola, Rolf A. Heckemann, Anna Castrioto, Lèon Tremblay, Vèronique Sgambato, Emmanuel Broussolle, Paul Krack, Stèphane Thobois
Early limbic microstructural alterations in apathy and depression in de novo Parkinson's disease
Movement Disorders, 1644--1654, Vol: 34, (2019), doi: 10.1002/mds.27793 - Eva Martinez, Benjamin Pasquereau, Yosuke Saga, Èlise Mètèreau, Lèon Tremblay
The Anterior Caudate Nucleus Supports Impulsive Choices Triggered by Pramipexole
Movement Disorders, 296--305, Vol: 35, (2019), doi: 10.1002/mds.27898 - Eva Martinez, Benjamin Pasquereau, Yosuke Saga, Èlise Mètèreau, Lèon Tremblay
The Anterior Caudate Nucleus Supports Impulsive Choices Triggered by Pramipexole
Movement Disorders, 296--305, Vol: 35, (2019), doi: 10.1002/mds.27898 - Maude Beaudoin-Gobert, Elise Mètèreau, Sandra Duperrier, Stèphane Thobois, Lèon Tremblay, Vèronique Sgambato
Pathophysiology of levodopa-induced dyskinesia: Insights from multimodal imaging and immunohistochemistry in non-human primates
NeuroImage, 132--141, Vol: 183, (2018), doi: 10.1016/j.neuroimage.2018.08.016 - Yosuke Saga, Christian C. Ruff, Lèon Tremblay
Disturbance of approach-avoidance behaviors in non-human primates by stimulation of the limbic territories of basal ganglia and anterior insula
European Journal of Neuroscience, 687--700, Vol: 49, (2018), doi: 10.1111/ejn.14201 - Stephane Thobois, Stephane Prange, Vèronique Sgambato-Faure, Lèon Tremblay, Emmanuel Broussolle
Imaging the Etiology of Apathy, Anxiety, and Depression in Parkinson's Disease: Implication for Treatment
Current Neurology and Neuroscience Reports, Vol: 17, (2017), doi: 10.1007/s11910-017-0788-0 - Stephane Thobois, Stephane Prange, Vèronique Sgambato-Faure, Lèon Tremblay, Emmanuel Broussolle
Imaging the Etiology of Apathy, Anxiety, and Depression in Parkinson's Disease: Implication for Treatment
Current Neurology and Neuroscience Reports, Vol: 17, (2017), doi: 10.1007/s11910-017-0788-0 - Yosuke Saga, Eiji Hoshi, Lèon Tremblay
Roles of Multiple Globus Pallidus Territories of Monkeys and Humans in Motivation, Cognition and Action: An Anatomical, Physiological and Pathophysiological Review
Frontiers in Neuroanatomy, Vol: 11, (2017), doi: 10.3389/fnana.2017.00030 - Benedicte Ballanger, Maude Beaudoin-Gobert, Sara Neumane, Justine Epinat, Elise Metereau, Sandra Duperrier, Emmanuel Broussolle, Stephane Thobois, Frederic Bonnefoi, Christian Tourvielle, Franck Lavenne, Nicolas Costes, Didier Lebars, Luc Zimmer, Vèronique Sgambato-Faure, Lèon Tremblay
Imaging Dopamine and Serotonin Systems on MPTP Monkeys: A Longitudinal PET Investigation of Compensatory Mechanisms
The Journal of Neuroscience, 1577--1589, Vol: 36, (2016), doi: 10.1523/jneurosci.2010-15.2016 - Bènèdicte Ballanger, Lèon Tremblay, Vèronique Sgambato-Faure, Maude Beaudoin-Gobert, Franck Lavenne, Didier Le Bars, Nicolas Costes
A multi-atlas based method for automated anatomical Macaca fascicularis brain MRI segmentation and PET kinetic extraction
NeuroImage, 26--43, Vol: 77, (2013), doi: 10.1016/j.neuroimage.2013.03.029